Adity Gupta — Postdoctoral Fellow
PhD, Central Drug Research Institute (Lucknow, India).
Project Title: “Characterizing the role of the epigenetic enzyme JMJD3 in modulating the inflammatory response to injury during muscle regeneration.”
During muscle regeneration, satellite cells move through a sequence of tightly regulated cell-fate changes to repair damaged fibers. Each transition requires a precise shift in which genes are active, while proliferation also depends on a form of “cellular memory” that preserves key programs in progenitors. Adity is exploring how JMJD3 contributes to these transitions by tuning inflammatory gene programs. Understanding how epigenetic enzymes modulate inflammation during regeneration may reveal strategies to improve repair in disease and aging.
Research publications
- Gupta A, Kumar A, Singh N, Patel M, Studitsky VM, Zhang KYJ, Akhtar MS. The Ser7 of RNA Pol II-CTD influences the recruitment of Cdc73 for mRNA transcription. Int J Biol Macromol. 2023 Nov 8;254(Pt 2):127881.
- Gupta A, Kumar A, Singh N, Sudarshan N, Studitsky VM, Zhang KYJ, Akhtar MS. The Saccharomyces cerevisiae SR protein Npl3 interacts with hyperphosphorylated CTD of RNA Polymerase II. Int J Biol Macromol. 2023 Oct 18;253(Pt 7):127541.
- Khan A, Gupta A, Singh P, Mishra AK, Ranjan RK, Srivastava A. Siderophore-assisted cadmium hyperaccumulation in Bacillus subtilis. Int Microbiol. 2020;23(2):277–286.
- Gupta A, Singh A, Singh N, Ansari H, Studitsky VM, Akhtar MS. Cdc5 Phosphorylates the Ser7 of RNA Polymerase II CTD during the mitotic transcription (manuscript in preparation).
- Sudarshan N, Asalam M, Kumar A, Singh N, Gupta A, De I, Singh SK, Zhang KY, Akhtar MS. The Ser7 phosphorylation of RNA polymerase II-CTD is required for the recruitment of E3 ubiquitin ligase Asr1 and subtelomeric gene silencing. J. Biol. Chem. 2025 Jun 11:110365.
Patents
ANTIMICROBIAL PEPTIDE AND ITS COMPOSITION THEREOF.
Patent application number: 202411062020.